In fiction, the first few words or letters of a chapter are often either capitalized or formatted differently. Make these words consistent with the rest of the text. This may require changing the text to sentence case and re-capitalizing anything that needs to be recapitalized (such as proper names). We do this because some screenreaders read UPPERCASE words as separate letters (i.e. U-P-P-E-R-C-A-S-E) which sounds like an abbreviation and is annoying.
Excerpt of a book where drop caps and capitalization should be changed to sentence case: Drop caps and capitalization
#thisisanexample should be changed to #ThisIsAnExample
PHRASEINALLCAPSWITHNOSPACES should be changed to PhraseInAllCapsWithNoSpaces
Q: There is a name in my text that appears as follows: Richard III. Should I change it to Richard the 3rd?
A: No, TTS is smart and will pronounce it like "Richard the 3rd" :) Most always, we avoid editing the original writing in any way. We can change how the TTS pronounces words by adding specific tags into the code.