In fiction, the first few words of a chapter are often either capitalized or formatted differently. Make these words consistent with the rest of the text. This may require changing the text to sentence case and re-capitalize anything that needs to be recapitalized (such as proper names). We do this because some screenreaders read UPPERCASE words as separate letters (e.g. U-P-P-E-R-C-A-S-E) which sounds like an abbreviation and is annoying.

Excerpt of a book where drop caps and capitalization should be changed to sentence case: Drop caps and capitalization

Headings are an exception. All uppercase words in headings tend to be read as words, but if you want to change it, use capitalize each word or Title Case.

Change capitalization in Word

Q: There is a name in my text that appears as follows: Richard III. Should I change it to Richard the 3rd?

A: No, TTS is smart and will pronounce it like "Richard the 3rd" :) Most always, we avoid editing the text in any way (exceptions: if there are large chunks of text with strange capitalization, bold, italics, or underline). We can change how the TTS pronounces words by adding specific tags into the code.